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A Route to the Heterocyclic Cluster of the E‑Series of Thiopeptide Antibiotics

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journal contribution
posted on 17.04.2015 by Hee-Jong Hwang, Marco A. Ciufolini
A concise route to the 3-hydroxypyridine core of thiopeptide antibiotics such as nocathiacin is described. Key phases of the sequence involve a modified Hantzsch pyridine construction and a chemoselective Peng deprotection of a phenolic MOM ether.

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