A Route to the Heterocyclic Cluster of the E‑Series of Thiopeptide Antibiotics
journal contributionposted on 17.04.2015 by Hee-Jong Hwang, Marco A. Ciufolini
Any type of content formally published in an academic journal, usually following a peer-review process.
A concise route to the 3-hydroxypyridine core of thiopeptide antibiotics such as nocathiacin is described. Key phases of the sequence involve a modified Hantzsch pyridine construction and a chemoselective Peng deprotection of a phenolic MOM ether.