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A Novel Functional Translocator Protein Ligand for Cancer Imaging

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journal contribution
posted on 21.11.2007 by Mingfeng Bai, Malena B. Rone, Vassilios Papadopoulos, Darryl J. Bornhop
The translocator protein (TSPO) is an attractive target for tumor imaging due to its up-regulation in numerous cancer cell types. Here, we report a series of functional TSPO ligands, n-TSPOmbb732, which can be conjugated to a variety of signaling moieties and are widely applicable in TSPO-targeted molecular imaging. Two fluorescent dye-labeled 6-TSPOmbb732 displayed nanomolar binding affinities to TSPO and were successfully imaged in vitro.

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