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A Novel Anionic Condensation, Fragmentation, and Elimination Reaction of Bicyclo[2.2.1]heptenone Ring Systems

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journal contribution
posted on 17.05.1999 by Jon D. Rainier, Qing Xu
We have identified an unprecedented anionic condensation, fragmentation, and elimination sequence from the coupling of bicyclo[2.2.1]heptenones with aldehydes. This reaction leads to the stereoselective formation of disubstituted five-membered rings which are present in a wide array of bioactive molecules.