A Luminescent and Biocompatible PhotoCORM
journal contributionposted on 07.11.2012 by Agustin E. Pierri, Alessia Pallaoro, Guang Wu, Peter C. Ford
Any type of content formally published in an academic journal, usually following a peer-review process.
The water-soluble rhenium(I) complex fac-[Re(bpy)(CO)3(thp)]+ (1) [CF3SO3– salt; bpy = 2,2′-bipyridine, thp = tris(hydroxymethyl)phosphine] is both strongly luminescent and photoactive toward carbon monoxide release. It is stable in aerated aqueous media, is incorporated into cells from the human prostatic carcinoma cell line PPC-1, and shows no apparent cytotoxicity. Furthermore, the solvated Re(I) photoproduct of CO release (2) is also luminescent, a feature that allows one to track the transformation of 1 to 2 inside such cells using confocal fluorescence microscopy. In this context, 1 is a very promising candidate as a photoactivated CO releasing moiety (photoCORM) with potential therapeutic applications.