A Highly Selective Chemosensor for Al(III) and Zn(II) and Its Coordination with Metal Ions
journal contributionposted on 17.03.2014 by Wei Cao, Xiang-Jun Zheng, Ji-Ping Sun, Wing-Tak Wong, De-Cai Fang, Jia-Xin Zhang, Lin-Pei Jin
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This paper reports a fluorescence chemosensor, N-(benzimidazol-2-yl)salicylaldimine (H2L), for Zn(II) and Al(III) ions. H2L has high selectivity for Al(III) in dimethyl sulfoxide (DMSO) and for Zn(II) in N,N-dimethylformamide (DMF). In methanol, Zn(II) and Al(III) could also be distinguished by H2L with different excitation wavelengths. The fluorescent species [Zn(HL)(H2O)(CH3OH)]+, [Zn(HL)(H2O)(DMF)]+, [Al(HL)2(OH)(H2O)], and [Al(HL)(OH)2(H2O)(DMSO)] formed in solution were established by a combination of experimental and theoretical methods, including Job’s plot, 1H NMR titration, electrospray inonization mass spectrometry (ESI-MS), and B3LYP-SCRF/6-31(d) and TD-B3LYP-SCRF/6-31G* density functional theory methods. The results show that Zn(II) and Al(III) are all coordinated to the imine nitrogen atom and the hydroxyl oxygen atom from H2L, which is the same as the M2+ ions in the obtained mononuclear complexes [M(HL)2(CH3OH)2] (where M = Cd, Ni, Co, and Mg). The detection limits of H2L for Zn(II) were 5.98 μM in methanol and 5.76 μM in DMF, while the detection limits of H2L for Al(III) were 3.3 μM in methanol and 5.25 μM in DMSO. Furthermore, it is also confirmed that H2L has low toxicity for HeLa cells and could be used to detect Zn(II) and Al(III) ions in living cells by bioimaging.