A Highly Chemoselective, Zr-Catalyzed C–O Bond Functionalization of Benzofuran
journal contributionposted on 14.10.2013 by Shuhui Yow, Adi E. Nako, Léonard Neveu, Andrew J. P. White, Mark R. Crimmin
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The chemoselective C–O bond functionalization of benzofuran with an aluminum dihydride may be catalyzed by zirconocene dichlorides. The reaction proceeds with the formal addition of a C–O bond to, and elimination of dihydrogen from, aluminum. The product of C–O bond alumination reacts with benzaldehyde via insertion of the carbonyl into the newly formed Al–C bond.