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A Concise and Modular Synthesis of Pyranicin

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journal contribution
posted on 06.11.2008, 00:00 by Nolan D. Griggs, Andrew J. Phillips
A modular, 13-step synthesis of the tetrahydropyran-containing annonaceous acetogenin pyranicin is reported. Key features are the use of an Achmatowicz oxidation−Kishi reduction sequence for the assembly of a pyranone from a furan and the application of Fu’s alkyl−alkyl Suzuki coupling for subunit union.