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A Class of Amide Ligands Enable Cu-Catalyzed Coupling of (Hetero)aryl Halides with Sulfinic Acid Salts under Mild Conditions

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journal contribution
posted on 22.05.2018 by Jinlong Zhao, Songtao Niu, Xi Jiang, Yongwen Jiang, Xiaojing Zhang, Tiemin Sun, Dawei Ma
The amide derived from 4-hydroxy-l-proline and 2,6-dimethylaniline is a powerful ligand for Cu-catalyzed coupling of (hetero)­aryl halides with sulfinic acid salts, allowing the formation of a wide range of (hetero)­aryl sulfones from the corresponding (hetero)­aryl halides at considerably low catalytic loadings. The coupling of (hetero)­aryl iodides and sodium methanesulfinate proceeds at room temperature with only 0.5 mol % CuI and ligand, representing the first example for Cu-catalyzed arylation at both low catalytic loading and room temperature.