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1,4-Dideoxy-1,4-imino‑d‑arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α‑Mannosidase Inhibitors

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journal contribution
posted on 15.07.2020 by Marianne B. Haarr, Óscar Lopéz, Ljupcho Pejov, José G. Fernández-Bolaños, Emil Lindbäck, Magne O. Sydnes
The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (Ki values ranging from 0.23 to 1.4 μM).