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Structural Analogues of the Bimetallic Reaction Center in Acetyl CoA Synthase:  A Ni−Ni Model with Bound CO

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posted on 25.06.2003, 00:00 by Rachel C. Linck, Cameron W. Spahn, Thomas B. Rauchfuss, Scott R. Wilson
Models for the active site of the acetyl CoA synthase (ACS) were synthesized by attachment of Cu+ and Ni(0) to nickel diaminodithiolate (S2N2) and diamidodithiolate (S2N2‘) complexes. The Ni−Ni species form stable CO adducts, i.e., [{(CO)2Ni}{NiS2N2‘}]2-, whereas the Cu-NiS2N2 and Cu-NiS2N2‘ models do not. These results provide supporting evidence for a biological role for reduced nickel in ACS.