N‑Bromosuccinimide-Induced Aminocyclization–Aziridine Ring-Expansion Cascade: An Asymmetric and Highly Stereoselective Approach toward the Synthesis of Azepane
datasetposted on 18.04.2014, 00:00 by Jing Zhou, Ying-Yeung Yeung
A novel N-bromosuccinimide induced aminocyclization–aziridine ring expansion cascade is reported. Substituted azepanes were isolated exclusively in good yields. The azepane products could be transformed into a number of functional molecules including piperidines, a bicyclic amine, and a bridgehead amide.