posted on 2023-01-13, 05:14authored byZhi-Yong Jiang, Chun-Jiang Liu, Qi Niu, Xin-Yu Yan, Die Xiao, Hong-Lei Zhang, Chun-Qiu Huang, Sheng-Li Shi, Ai-Xue Zuo, Hong-Ping He
Fifteen compounds including nine
new diterpenes were isolated from
the roots of Croton yunnanensis. By HRESIMS, NMR,
ECD data, and X-ray diffraction analysis, the new compounds were characterized
as eight neo-clerodane diterpenes (compounds 1–8) and one 15,16-dinor-ent-pimarane diterpene (9). All diterpenes were assayed
for their hypoglycemic activities. Compounds 1–4, 6, 7, and 10 promoted
glucose uptake activity in insulin-resistant 3T3-L1 adipocytes. Compounds 1 and 6 showed insulin sensitizing activity,
potentiating conspicuously their glucose uptake activity at a concentration
of 20 μM when treated synergistically with low-concentration
insulin at 1 nM.