ol9014943_si_002.cif (42.22 kB)

B-Alkylcatecholborane-Mediated Tandem Radical Conjugated Addition−Aldol Cyclization

Download (42.22 kB)
dataset
posted on 20.08.2009 by Alice Beauseigneur, Cecilia Ericsson, Philippe Renaud, Kurt Schenk
A one-pot procedure involving radical conjugate addition of B-alkylcatecholboranes to enones followed by intramolecular aldol reaction is reported. Application to the stereoselective synthesis of monocyclic and bicyclic products with up to four contiguous stereogenic centers is presented.

History

Exports