ol500873s_si_002.cif (45 kB)
α‑Ketophosphonates as Ester Surrogates: Isothiourea-Catalyzed Asymmetric Diester and Lactone Synthesis
dataset
posted on 2014-05-02, 00:00 authored by Siobhan
R. Smith, Stuart M. Leckie, Reuben Holmes, James Douglas, Charlene Fallan, Peter Shapland, David Pryde, Alexandra M. Z. Slawin, Andrew D. SmithIsothiourea
HBTM-2.1 catalyzes the asymmetric Michael addition/lactonization
of aryl- and alkenylacetic acids using α-keto-β,γ-unsaturated
phosphonates as α,β-unsaturated ester surrogates, giving
access to a diverse range of stereodefined lactones or enantioenriched
functionalized diesters upon ring-opening.
