jo7b03255_si_002.cif (1.79 MB)

(3+2) Cycloadditions of Thiouronium Ylides: A Room-Temperature, One-Pot Approach to Dihydrothiophenes

Download (1.79 MB)
dataset
posted on 06.02.2018, 16:19 by James D. Neuhaus, Peter Angyal, Rik Oost, Nuno Maulide
A room-temperature (3+2) cycloaddition sequence for the synthesis of highly substituted dihydrothiophene derivatives has been developed. By utilizing structurally unique thiocarbonyl ylides, the reactivity of these traditionally high-energy intermediates can be modulated, enabling a synthetically useful transformation to proceed under mild conditions.

History

Exports