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[3 + 2] Cycloaddition of Azaoxyallyl Cations with Cyclic Ketones: Access to Spiro-4-oxazolidinones

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posted on 19.09.2017, 00:00 authored by Pan-Lin Shao, Zi-Rui Li, Zhi-Peng Wang, Ming-Hui Zhou, Qi Wu, Ping Hu, Yun He
The first formal [3 + 2] cycloaddition reaction of in situ generated azaoxyallyl cation with cyclic ketones has been developed using mild reaction conditions. A variety of spiro-4-oxazolidinones was obtained in excellent yields (up to 99%). The high efficiency of this process, coupled with the operational simplicity, makes it an attractive method for the synthesis of spiro-4-oxazolidinones.