jo5b01924_si_001.cif (231.34 kB)
Yb(OTf)3‑Mediated Access to Furans from β‑Ketothioamides via Eschenmoser Sulfide Contraction Reaction
dataset
posted on 2015-12-18, 00:00 authored by Ming Li, Xiang-Jing Kong, Li-Rong WenA mild and straightforward synthetic
protocol for construction
of a furan skeleton promoted by Yb(OTf)3 from β-ketothioamides
and arylglyoxals has been developed at room temperature. Importantly,
this protocol involves a tandem sequence that includes aldol condensation,
N-cyclization, ring opening, O-cyclization, S-cyclization, and Eschenmoser
sulfide contraction.
