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Xanthepinone, an Antimicrobial Polyketide from a Soil Fungus Closely Related to Phoma medicaginis

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posted on 23.10.2009, 00:00 by Johannes C. Liermann, Heinz Kolshorn, Till Opatz, Eckhard Thines, Heidrun Anke
The isolation, biological characterization, and structure elucidation of xanthepinone, a novel antifungal metabolite isolated from the broth of submerged cultures of a soil fungus, are described. Xanthepinone inhibits the conidial germination of Magnaporthe grisea (2 μg/mL), Phytophthora infestans (5 μg/mL), and Botrytis cinerea (10 μg/mL) while showing only weak antibacterial activity; cytotoxicity was not observed up to 50 μg/mL. Molecular taxonomy revealed that the producing strain is close to species in the genus Phoma as well as to uncultured soil fungi and endophytes.