ol7b02173_si_002.cif (916.56 kB)
Walrobsins A and B, Two Anti-inflammatory Limonoids from Root Barks of Walsura robusta
dataset
posted on 2017-08-18, 18:48 authored by Fa-Liang An, Dong-Mei Sun, Rui-Jun Li, Miao-Miao Zhou, Ming-Hua Yang, Yong Yin, Ling-Yi Kong, Jun LuoWalrobsins
A (1) and B (2), two limonoids
featuring an unprecedented 5-oxatricyclo[5.4.11,4]hendecane ring system, were isolated from the root barks of Walsura robusta. Their structures, including their absolute
configurations, were determined by analyses of HR-ESIMS, 1D/2D NMR,
and X-ray crystallography. Compounds 1 and 2 possessed a stable hemiketal structure formed between the OH-11
and 3-carbonyl group in the hexatomic oxoheterocyclic ring. Compound 1 showed significant anti-inflammatory activity with an IC50 value of 7.8 μM and inhibited the expression of iNOS
and IL-1β in a dose-dependent manner.
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hemiketal structureIL -1βconfigurationanti-inflammatory activitydose-dependent mannerWalsura robusta WalrobsinsWalsura robustalimonoidIC 50 valuehendecanehexatomic oxoheterocyclic ring3- carbonyl group7.8 μ MHR-ESIMSX-ray crystallographyCompounds 1analysesRoot BarksNMRoxatriexpressionCompound 15-Anti-inflammatory LimonoidsOH -11iNOS
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