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Walrobsins A and B, Two Anti-inflammatory Limonoids from Root Barks of Walsura robusta

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posted on 18.08.2017 by Fa-Liang An, Dong-Mei Sun, Rui-Jun Li, Miao-Miao Zhou, Ming-Hua Yang, Yong Yin, Ling-Yi Kong, Jun Luo
Walrobsins A (1) and B (2), two limonoids featuring an unprecedented 5-oxatri­cyclo­[5.4.11,4]­hendecane ring system, were isolated from the root barks of Walsura robusta. Their structures, including their absolute configurations, were determined by analyses of HR-ESIMS, 1D/2D NMR, and X-ray crystallography. Compounds 1 and 2 possessed a stable hemiketal structure formed between the OH-11 and 3-carbonyl group in the hexatomic oxoheterocyclic ring. Compound 1 showed significant anti-inflammatory activity with an IC50 value of 7.8 μM and inhibited the expression of iNOS and IL-1β in a dose-dependent manner.