posted on 2015-07-01, 00:00authored byRong Zhu, Stephen L. Buchwald
A versatile method for the rapid
synthesis of diverse enantiomerically
enriched lactones has been developed based on Cu-catalyzed enantioselective
radical oxyfunctionalization of alkenes. The scope of this strategy
encompasses a series of enantioselective difunctionalization reactions:
oxyazidation, oxysulfonylation, oxyarylation, diacyloxylation, and
oxyalkylation. These reactions provide straightforward access to a
wide range of useful chiral lactone building blocks containing tetrasubstituted
stereogenic centers, which are hard to access traditionally.