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Download fileVersatile Enantioselective Synthesis of Functionalized Lactones via Copper-Catalyzed Radical Oxyfunctionalization of Alkenes
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posted on 2015-07-01, 00:00 authored by Rong Zhu, Stephen L. BuchwaldA versatile method for the rapid
synthesis of diverse enantiomerically
enriched lactones has been developed based on Cu-catalyzed enantioselective
radical oxyfunctionalization of alkenes. The scope of this strategy
encompasses a series of enantioselective difunctionalization reactions:
oxyazidation, oxysulfonylation, oxyarylation, diacyloxylation, and
oxyalkylation. These reactions provide straightforward access to a
wide range of useful chiral lactone building blocks containing tetrasubstituted
stereogenic centers, which are hard to access traditionally.
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seriesoxyfunctionalizationenantiomericallyAlkenetetrasubstituted stereogenic centersstrategyaccessenantioselective difunctionalization reactionsscopeFunctionalized LactonesdiacyloxylationmethodsynthesisalkeneoxyalkylationoxyazidationVersatile Enantioselective Synthesischiral lactone building blocksOxyfunctionalizationoxysulfonylationRadicaloxyarylation