posted on 2022-12-14, 15:42authored bySouvik Misra, Pijush Singh, Ajeet Kumar Singh, Lisa Roy, Soumen Kuila, Sukantha Dey, Ajit K. Mahapatra, Jayanta Nanda
Helical supramolecular architectures play important structural
and functional roles in biological systems. The helicity of synthetic
molecules can be tuned mainly by the chiral manipulation of the system.
However, tuning of helicity by the achiral unit of the molecules is
less studied. In this work, the helicity of naphthalimide-capped peptide-based
gel nanofibers is tuned by the alteration of methylene units present
in the achiral amino acid. The inversion of supramolecular helicity
has been extensively studied by CD spectroscopy and morphological
analysis. The density functional theory (DFT) study indicates that
methylene spacers influence the orientation of π–π
stacking interactions of naphthalimide units in the self-assembled
structure that regulates the helicity. This work illustrates a new
approach to tuning the supramolecular chirality of self-assembled
biomaterials.