cs8b01720_si_002.cif (271.11 kB)

Trifunctionalization of Allenes via Cobalt-Catalyzed MHP-Assisted C–H Bond Functionalization and Molecular Oxygen Activation

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posted on 12.06.2018 by Shengxian Zhai, Shuxian Qiu, Xiaoming Chen, Cheng Tao, Yun Li, Bin Cheng, Huifei Wang, Hongbin Zhai
We have developed an approach for the cobalt-catalyzed trifunctionalization of allenes to form versatile 3-acylquinolines in the presence of molecular oxygen with moderate to good yields in high regioselectivity. C–H bond functionalization of benzoic hydrazides assisted by the 2-(1′-methylhydrazinyl)­pyridine (MHP) acted as a key step in the cascade reaction. The reaction shows broad functional group tolerance of both allenes and hydrazides. Moreover, relevant experiments have been performed to probe the reaction mechanism.