posted on 2017-06-20, 14:49authored byAntoine Bruneau-Voisine, Ding Wang, Vincent Dorcet, Thierry Roisnel, Christophe Darcel, Jean-Baptiste Sortais
A very simple and inexpensive catalytic
system based on abundant
manganese as transition metal and on an inexpensive phosphine-free
bidendate ligand, 2-(aminomethyl)pyridine, has been developed for
the reduction of a large variety of carbonyl derivatives with 2-propanol
as hydrogen donor. Remarkably, the reaction proceeds at room temperature
with low catalyst loading (down to 0.1 mol %) and exhibits a good
tolerance toward functional groups. High TON (2000) and TOF (3600
h–1) were obtained.