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Total Synthesis of (±)-Sculponeatin N

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posted on 03.01.2014, 00:00 by Zhiqiang Pan, Cunying Zheng, Hongyu Wang, Yanhe Chen, Yun Li, Bin Cheng, Hongbin Zhai
The first total synthesis of the (±)-sculponeatin N (a 6,7-seco-ent-kaurane diterpenoid discovered by Sun and co-workers) has been achieved. The features include a regio- and stereoselective aldol reaction to form a lactone, an intramolecular Diels–Alder reaction to install B and C rings simultaneously, and a radical cyclization to forge the D ring.