ol900237e_si_003.cif (22.72 kB)

Total Synthesis of Phomactin A

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posted on 02.04.2009, 00:00 by Yu Tang, Kevin P. Cole, Grant S. Buchanan, Gang Li, Richard P. Hsung
A total synthesis of (±)-phomactin A is described to highlight the final completion of a complex natural product target that had commenced with an intramolecular oxa-[3 + 3] annulation strategy in the construction of the ABD-tricycle. These efforts reveal structural intricacies of this ABD-tricycle with an illustrative example being the conformational analysis that was ultimately critical for the C5a-homolgation.