American Chemical Society
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Total Synthesis of (−)-Chromodorolide B

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posted on 2016-02-16, 00:00 authored by Daniel J. Tao, Yuriy Slutskyy, Larry E. Overman
The first total synthesis of a chromodorolide diterpenoid is described. The synthesis features a bimolecular radical addition/cyclization/fragmentation cascade that unites butenolide and trans-hydrindane fragments while fashioning two C–C bonds and stereoselectively forming three of the ten contiguous stereocenters of chromodorolide B.