American Chemical Society
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Total Synthesis of Azumamide E and Sugar Amino Acid-Containing Analogue

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posted on 2009-01-02, 00:00 authored by Srivari Chandrasekhar, Chennamaneni Lohitha Rao, Mallikanti Seenaiah, Police Naresh, Bharatam Jagadeesh, Dharani Manjeera, Arpita Sarkar, Manika Pal Bhadra
An efficient and practical total synthesis of marine cyclic tetrapeptide, natural product azumamide E (1) is achieved via high-yielding reactions. The strategy also allowed us to synthesize the azumamide E-SAA (sugar amino acid) analogue (2), whose solution-phase NMR and biological activity studies were also carried out.