posted on 2020-02-14, 15:34authored byYinliang Guo, Zhixian Guo, Jia-Tian Lu, Runting Fang, Si-Cong Chen, Tuoping Luo
An enantioselective
total synthesis of (−)-batrachotoxinin
A is accomplished based on a key photoredox coupling reaction and
the subsequent local-desymmetrization operation. After the expedient
assembly of the highly oxidized steroid skeleton, a delicate sequence
of redox manipulations was carried out to deliver a late-stage intermediate
on gram scaleand ultimately (−)-batrachotoxinin
A in an efficient manner.