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Total Syntheses of (+)-Lyconadin A and (−)-Lyconadin B

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posted on 02.04.2020, 14:16 by Douglas C. Beshore, Amos B. Smith
The enantioselective syntheses of (+)-lyconadin A and (−)-lyconadin B are described. Key bond constructions include a strategy-level intramolecular aldol/conjugate addition cascade, an olefin aminoiodination, and a novel one-pot α-pyridinone annulation.