Three-Component Synthesis of α,β-Cyclopropyl-γ-Amino Acids
datasetposted on 17.03.2005, 00:00 by Peter Wipf, Corey R. J. Stephenson
The multicomponent coupling of alkenylzirconocenes with N-diphenylphosphinoyl imines provides rapid access to functionalized C-cyclopropylalkylamides which have been readily transformed into α,β-cyclopropyl-γ-amino acids. These novel scaffolds are thus accessible in ca. 8 steps from commercially available alkynes.