ol0501525_si_002.cif (24.46 kB)

Three-Component Synthesis of α,β-Cyclopropyl-γ-Amino Acids

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posted on 17.03.2005, 00:00 by Peter Wipf, Corey R. J. Stephenson
The multicomponent coupling of alkenylzirconocenes with N-diphenylphosphinoyl imines provides rapid access to functionalized C-cyclopropylalkylamides which have been readily transformed into α,β-cyclopropyl-γ-amino acids. These novel scaffolds are thus accessible in ca. 8 steps from commercially available alkynes.