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Thermal Cycloisomerization of Putative Allenylpyridines for the Synthesis of Isoquinoline Derivatives

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posted on 04.08.2016, 18:53 by Alec E. Morrison, Jeremy J. Hrudka, Gregory B. Dudley
A cascade (cyclo)­isomerization/elimination process produces novel isoquinoline derivatives of potential interest for pharmaceutical, biomedical, and energy-related research. Mechanistic experiments support a putative allenylpyridine (reminiscent of the Garratt–Braverman cyclization) as a key intermediate in the cascade process.