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Tetracyclic Terpenoids from Dasyscyphus niveus, Dasyscyphins D and E

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posted on 26.09.2008 by Johannes C. Liermann, Heinz Kolshorn, Heidrun Anke, Eckhard Thines, Till Opatz
Cultures of the ascomycete Dasyscyphus niveus have yielded two new tetracyclic dasyscyphin-type terpenoids (1 and 2), and their structures were elucidated by NMR spectroscopy and X-ray crystallography. The absolute configuration of dasyscyphin D (1) was determined by synthesis and NMR spectroscopy of diastereomeric MTPA esters. Both compounds inhibited the germination of conidia of Magnaporthe grisea at 25 μg/mL.