Temperature-Driven Switching of Helical Chirality of
Poly[(4-carboxyphenyl)acetylene] Induced by a Single Amidine
Enantiomer and Memory of the Diastereomeric Macromolecular
Helicity
Two novel optically active amidines, (R,R)-N,N‘-bis(1-phenylethyl)-2,4,6-triphenylbenzamidine
[(R,R)-2] and (R,R)-N,N‘-bis(1-phenylethyl)benzamidine [(R,R)-3] were synthesized, and their helicity induction
abilities for poly[(4-carboxyphenyl)acetylene] (poly-1) in dimethyl sulfoxide (DMSO) were investigated by
UV−visible and circular dichroic spectroscopies. Poly-1 exhibited a split-type induced circular dichroism (ICD)
in the polymer backbone region in the presence of the optically active amidines due to a predominantly one-handed helical conformation. The ICD pattern of poly-1 complexed with the bulky (R,R)-2 ([(R,R)-2]/[poly-1] =
1) dramatically changed in DMSO and the Cotton effect signs reversibly inverted by changing the temperature,
whereas the complex of poly-1 with the less bulky (R,R)-3 complex did not show such a temperature-driven
change in the ICD. These results indicate that the helix-sense of poly-1 induced by (R,R)-2 through noncovalent
acid−base interactions undergoes a transition from one helix to another in response to temperature. Furthermore,
the diastereomeric right- and left-handed helices of poly-1 induced by (R,R)-2 at different temperatures could be
separately memorized by the replacement of (R,R)-2 with achiral amines, thus generating enantiomeric helices of
the mirror images of each other.