jo502634h_si_002.cif (11.16 kB)
Tandem Synthesis of 3‑Chloro-4-iodoisoxazoles from 1‑Copper(I) Alkynes, Dichloroformaldoxime, and Molecular Iodine
dataset
posted on 2015-02-20, 00:00 authored by Wenwen Chen, Jianlan Zhang, Bo Wang, Zhouxing Zhao, Xinyan Wang, Yuefei HuA tandem synthesis
for structurally novel 3-chloro-4-iodoisoxazoles
was developed by simply mixing 1-copper(I) alkynes, dichloroformaldoxime,
and molecular iodine together. The combination of 1-copper(I) alkyne
and molecular iodine was well used as a synthetic equivalent of 1-iodoalkyne
without the need for tedious preparation, purification, and storage
of 1-iodoalkyne.
