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Tandem Reactions of 1,2-Allenic Ketones Leading to Substituted Benzenes and α,β-Unsaturated Nitriles

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posted on 07.10.2011, 00:00 authored by Xinying Zhang, Xuefei Jia, Liangliang Fang, Nan Liu, Jianji Wang, Xuesen Fan
One-pot double Michael addition/intramolecular aldol reaction/decarboxylation of 1,2-allenic ketones with cyanoacetate offers an efficient and convenient approach to highly functionalized benzenes. With 2-substituted cyanoacetates, the reaction proceeds via a different tandem process to afford α,β-unsaturated nitriles effectively.