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Tandem Oxidative Dearomatizing Spirocyclizations of Propargyl Guanidines and Ureas

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posted on 21.07.2017 by Ravi P. Singh, Jayanta Das, Muhammed Yousufuddin, Delphine Gout, Carl J. Lovely
Treatment of propargyl ureas or guanidines with iodosobenzene diacetate results in an oxidative tandem amination/etherification dearomatizing spirocyclization. This transformation leads directly to the complete framework of the Leucetta alkaloids, spirocalcaridine A and B.

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