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Tandem Oxidative Dearomatizing Spirocyclizations of Propargyl Guanidines and Ureas

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posted on 21.07.2017, 17:38 authored by Ravi P. Singh, Jayanta Das, Muhammed Yousufuddin, Delphine Gout, Carl J. Lovely
Treatment of propargyl ureas or guanidines with iodosobenzene diacetate results in an oxidative tandem amination/etherification dearomatizing spirocyclization. This transformation leads directly to the complete framework of the Leucetta alkaloids, spirocalcaridine A and B.