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Tandem Diels−Alder Cycloadditions of 2-Pyrone-5-acrylates for the Efficient Synthesis of Novel Tetracyclolactones

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posted on 18.08.2006, 00:00 by Soo-Im Chung, Joobeom Seo, Cheon-Gyu Cho
Readily prepared from the regioselective Pd-catalyzed coupling reactions of 3,5-dibromo-2-pyrone, 3-bromo-2-pyrone-5-carboxylates undergo tandem uninterrupted sequential Diels−Alder cycloaddition reactions with allyl vinyl ethers in a highly regio- and stereoselective fashion to provide a series of novel tetracyclolactones in good yields.