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Talascortenes A–G, Highly Oxygenated Diterpenoid Acids from the Sea-Anemone-Derived Endozoic Fungus Talaromyces scorteus AS-242

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posted on 19.08.2020, 19:37 by Ling-Hong Meng, Xiao-Ming Li, Fan-Zhong Zhang, Ya-Nan Wang, Bin-Gui Wang
Eight new diterpenoid acids, namely, talascortenes A–G (17) and 5α,9β-dihydroxyisocupressic acid (8), with four different carbon skeletons, were isolated and identified from the endozoic fungal strain Talaromyces scorteus AS-242 that was obtained from the inner fresh tissue of a deep sea Cerianthus sp. sea anemone. The structures of the new compounds were elucidated by detailed interpretation of NMR and mass spectrometric data. X-ray crystallographic analysis of compounds 15 and 7 confirmed their structures and absolute configurations. Compounds 18 showed inhibitory activities against several human, aquatic, and plant pathogens with MIC values ranging from 1 to 32 μg/mL.

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