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Synthetic Access to Bent Polycycles by Cation-π Cyclization

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posted on 2010-08-06, 00:00 authored by Ryan A. Shenvi, E. J. Corey
The presence of an ether oxygen within a chain undergoing cation−polyene cyclization has a profound influence on the stereochemistry of this important construction, apparently due to nucleophilic participation of oxygen in the cyclization process and formation of an oxonium intermediate, leading to bent fused ring systems.