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Synthesis of the Pyoverdin Chromophore by a Biomimetic Oxidative Cyclization

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posted on 02.04.2009, 00:00 by Raymond C. F. Jones, Sze Chak Yau, James N. Iley, Janet E. Smith, James Dickson
The fluorescent dihydropyrimido[1,2-a]quinoline chromophore of the pyoverdin siderophores has been synthesized by a biomimetic oxidative cyclization using an iodine(III) reagent, followed by elimination and dehydrogenation.