posted on 2008-02-15, 00:00authored byJohn Limanto, C. Scott Shultz, Benjamin Dorner, Richard A. Desmond, Paul N. Devine, Shane W. Krska
Asymmetric hydrogenation of allylic dimethylcarbinamide
2 with 1 mol % of cationic Rh(I)−Josiphos complex in THF
under 500 psi of H2 generated the corresponding tertiary
carbinamide 1 in 98.5% assay yield and a 94:6 enantiomeric
ratio. Upon crystallization, the product was isolated in 91%
isolated yield and 95:5 enantiomeric ratio.