jo8b02404_si_002.cif (214.23 kB)
Synthesis of a Polycyclic Halichondrin C1–C14 Fragment via Intermolecular Oxy-Michael/Trans-Ketalization
dataset
posted on 2018-11-05, 00:00 authored by Dae-Shik Kim, Francis G. Fang, Hyeong-wook Choi, Hui FangSyntheses
of a crystalline polycyclic halichondrin C1–C14
building block starting from a d-gulono-1,4-lactone-derived
intermediate in the current Halaven manufacturing process are described.
Key features of the syntheses include an acid-catalyzed tandem intermolecular
oxy-Michael/intramolecular trans-ketalization reaction
and stereoselective Kishi reductions.
