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Synthesis of Trifluoromethylated Naphthoquinones via Copper-Catalyzed Cascade Trifluoromethylation/Cyclization of 2‑(3-Arylpropioloyl)benzaldehydes

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posted on 06.03.2017, 16:20 by Yan Zhang, Dongmei Guo, Shangyi Ye, Zhicheng Liu, Gangguo Zhu
A novel copper-catalyzed cascade trifluoromethylation/cyclization of 2-(3-arylpropioloyl)­benzaldehydes is described, allowing a direct access to structurally diverse trifluoromethylated naphthoquinones under mild reaction conditions. It represents the first trans-acyltrifluoromethylation of internal alkynes.