American Chemical Society
jo7b00990_si_003.cif (523.91 kB)

Synthesis of Spiro[indazole-3,3′-indolin]-2′-ones via [3 + 2] Dipolar Cycloaddition of Arynes with 3‑Diazoindolin-2-ones and Indazolo[2,3‑c]quinazolin-6(5H)‑ones by Subsequent Thermal Isomerization

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posted on 2017-07-04, 00:00 authored by Bin Cheng, Bing Zu, Bian Bao, Yun Li, Renqi Wang, Hongbin Zhai
An efficient protocol for facile construction of spiro­[indazole-3,3′-indolin]-2′-ones was developed via [3 + 2] dipolar cycloaddition of arynes with 3-diazoindolin-2-ones under mild conditions in excellent yields. Subsequent thermal isomerization of the spiro­[indazole-3,3′-indolin]-2′-ones readily afforded indazolo­[2,3-c]­quinazolin-6­(5H)-ones.