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Synthesis of Quinolinones with Palladium-Catalyzed Oxidative Annulation between Acrylamides and Arynes

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posted on 06.03.2015, 00:00 by Weiguo Wang, Xianglong Peng, Xiaoyu Qin, Xiangyun Zhao, Chen Ma, Chen-Ho Tung, Zhenghu Xu
An unprecedented palladium-catalyzed oxidative annulation of acrylamides with benzyne precursors has been successfully developed. By using this mild “N–H activation/Heck reaction” method, a wide variety of quinolinones were conveniently prepared in one step with high efficiency.