jo5b00335_si_002.cif (20.76 kB)

Synthesis of Polyhydroxylated Piperidine and Pyrrolidine Peptidomimetics via One-Pot Sequential Lactam Reduction/Joullié–Ugi Reaction

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posted on 03.04.2015, 00:00 by Piotr Szcześniak, Elżbieta Maziarz, Sebastian Stecko, Bartłomiej Furman
A direct approach to the synthesis of polyhydroxylated piperidine and pyrrolidine peptidomimetics is described. The presented strategy is based on one-pot reduction of sugar-derived lactams with Schwartz’s reagent followed by a multicomponent Ugi–Joullié reaction.