ol7b03309_si_002.cif (390.84 kB)

Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation

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posted on 16.11.2017, 16:20 by Zhengbo Zhu, Xin Lv, Jason E. Anesini, Daniel Seidel
α-Ketoamides undergo redox-annulations with cyclic secondary amines, such as 1,2,3,4-tetrahydroisoquinoline, pyrrolidine, piperidine, and morpholine. Catalytic amounts of benzoic acid significantly accelerate these transformations. This approach provides polycyclic imidazolidinone derivatives in typically good yields.