posted on 2016-11-15, 20:04authored byPeng Gao, Juan Wang, Zi-Jing Bai, Li Shen, Yun-Yun Yan, De-Suo Yang, Ming-Jin Fan, Zheng-Hui Guan
A novel K2S2O8-promoted oxidative
cyclization of enamines is described. A variety of enamines having
diverse functional groups and substitution patterns react well using
K2S2O8 as the oxidant in the absence
of catalyst. This protocol provides a very simple route for the synthesis
of polycarbonyl pyrroles and has the advantages of readily available
starting materials, mild reaction conditions, and a wide scope of
substrates.