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Download fileSynthesis of Polycarbonyl Pyrroles via K2S2O8‑Mediated Oxidative Cyclization of Enamines
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posted on 2016-11-15, 20:04 authored by Peng Gao, Juan Wang, Zi-Jing Bai, Li Shen, Yun-Yun Yan, De-Suo Yang, Ming-Jin Fan, Zheng-Hui GuanA novel K2S2O8-promoted oxidative
cyclization of enamines is described. A variety of enamines having
diverse functional groups and substitution patterns react well using
K2S2O8 as the oxidant in the absence
of catalyst. This protocol provides a very simple route for the synthesis
of polycarbonyl pyrroles and has the advantages of readily available
starting materials, mild reaction conditions, and a wide scope of
substrates.