American Chemical Society
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Synthesis of Oxindole-Based Bioorganometallic Kinase Inhibitors Incorporating One or More Ferrocene Groups

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posted on 2016-02-18, 13:27 authored by Jahangir Amin, Irina S. Chuckowree, Minghua Wang, Graham J. Tizzard, Simon J. Coles, John Spencer
A series of oxindole-containing ferrocenes has been synthesized, studied in the solid state by X-ray crystallography, and tested for in vitro kinase inhibition. Many compounds show low or submicromolar activities against DYRK isoforms and VEGFR2, which in certain cases have been rationalized by molecular docking studies.